Soon after South Korean police posted a press release boasting about seizing $5.6 million worth of cryptocurrency from 124 wealthy tax evaders, cops realized that they had mistakenly posted images that made it possible for a thief to quickly steal most of the seized assets.
PacBio’s ability to produce extremely long reads makes it a useful complement to Illumina. Indeed, PacBio machines are better at sequencing “confusing” genomes, such as those with many copies of the same gene, long stretches of repetitive motifs, and “structural variations” like large insertions or deletions, which may not show up in short-read sequences. For instance, PacBio was used to sequence a very difficult bacterium called Clostridium autoethanogenum, which contains repeats, nine copies of a single gene, and insertions from bacterial virus genomes — basically the genomic equivalent of a Thomas Pynchon novel.
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Detection is via allocating a slice of zeroed memory, in our case a gigabyte, and then once per minute going through to ensure they're actually all zeroes. Magic!
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